Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination

by Chew, K.C.M., Matsuda, N., Saisho, K., Lim, G.G.Y., Chai, C., Tan, H.-M., Tanaka, K., Lim, K.-L.
Published 2014

A defined xeno-free and feeder-free culture system for the derivation, expansion and direct differentiation of transgene-free patient-specific induced pluripotent stem cells

by Lu, H.F., Chai, C., Lim, T.C., Leong, M.F., Lim, J.K., Gao, S., Lim, K.L., Wan, A.C.A.
Published 2014

The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin

by Yu, W.-P., Tan, J.M.M., Chew, K.C.M., Oh, T., Kolatkar, P., Venkatesh, B., Dawson, T.M., Lim, K.L.
Published 2014

Genetic or pharmacological activation of the Drosophila PGC-1? ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease

by Ng C.-H., Basil A.H., Hang L., Tan R., Goh K.-L., O'Neill S., Zhang X., Yu F., Lim K.-L.
Published 2018

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

by Sriram S.R., Li X., Ko H.S., Chung K.K.K., Wong E., Lim K.L., Dawson V.L., Dawson T.M.
Published 2018

Loss of locus coeruleus neurons and reduced startle in parkin null mice

by Von Coelln R., Thomas B., Savitt J.M., Lim K.L., Sasaki M., Hess E.J., Dawson V.L., Dawson T.M.
Published 2018

A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson's Disease

by Li L., Zhang C.-W., Ge J., Qian L., Chai B.-H., Zhu Q., Lee J.-S., Lim K.-L., Yao S.Q.
Published 2018

Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

by Lim, G.G., Chew, K.C., Ng, X.H., Henry-Basil, A., Sim, R.W., Tan, J.M., Chai, C., Lim, K.L.
Published 2016

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease

by Haskin, J., Szargel, R., Shani, V., Mekies, L.N., Rott, R., Lim, G.G.Y., Lim, K.-L., Bandopadhyay, R., Wolosker, H., Engelender, S.
Published 2014

Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells

by Tan K.K.B., Lim W.W.M., Chai C., Kukumberg M., Lim K.L., Goh E.L.K., Yim E.K.F.
Published 2018

Puromycin Analogues Capable of Multiplexed Imaging and Profiling of Protein Synthesis and Dynamics in Live Cells and Neurons

by Ge J., Zhang C.-W., Ng X.W., Peng B., Pan S., Du S., Wang D., Li L., Lim K.-L., Wohland T., Yao S.Q.
Published 2018

Parkin ubiquitinates the ?-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease

by Chung K.K.K., Zhang Y., Lim K.L., Tanaka Y., Huang H., Gao J., Ross C.A., Dawson V.L., Dawson T.M.
Published 2018

Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness

by De La Iglesia N., Konopka G., Lim K.-L., Nutt C.L., Bromberg J.F., Frank D.A., Mischel P.S., Louis D.N., Bonni A.
Published 2018

Flavokawain derivative FLS induced G2/M arrest and apoptosis on breast cancer MCF-7 cell line

by Ali, N.M., Akhtar, M.N., Ky, H., Lim, K.L., Abu, N., Zareen, S., Ho, W.Y., Alan-Ong, H.K., Tan, S.W., Alitheen, N.B., Ismail, J.B., Yeap, S.K., Kamarul, T.
Published 2016

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

by Wong, E.S.P., Tan, J.M.M., Soong, W.-E., Hussein, K., Nukina, N., Dawson, V.I., Dawson, T.M., Cuervo, A.M., Lim, K.-L.
Published 2014

AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease

by Ng, C.-H., Guan, M.S.H., Koh, C., Ouyang, X., Yu, F., Tan, E.-K., O'Neill, S.P., Zhang, X., Chung, J., Lim, K.-L.
Published 2014

A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson's disease models

by Li L., Zhang C.-W., Chen G.Y., Zhu B., Chai C., Xu Q.-H., Tan E.-K., Zhu Q., Lim K.-L., Yao S.Q.
Published 2018

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila

by Ng, C.-H., Mok, S.Z.S., Koh, C., Ouyang, X., Fivaz, M.L., Tan, E.-K., Dawson, V.L., Dawson, T.M., Yu, F., Lim, K.-L.
Published 2014

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

by Wong, E.S.P., Tan, J.M.M., Wang, C., Zhang, Z., Tay, S.-P., Zaiden, N., Han, S.K., Dawson, V.L., Dawson, T.M., Lim, K.-L.
Published 2014

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

by West A.B., Moore D.J., Choi C., Andrabi S.A., Li X., Dikeman D., Biskup S., Zhang Z., Lim K.-L., Dawson V.L., Dawson T.M.
Published 2018