MAPPING THE TRANSLATIONAL LANDSCAPE IN HUMAN CARDIAC FIBROSIS AND BEYOND

by SONIA PANKAJ CHOTHANI
Published 2022

Comparative investigation of worm positions for worm gearbox performance under no-load condition / Hardik G Chothani and Kalpesh D Maniya

by Chothani, Hardik G, Maniya, Kalpesh D
Published 2021

Discovering microproteins: making the most of ribosome profiling data

by Sonia Chothani, Lena Ho, Sebastian Schafer, Owen Rackham
Published 2024

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy

by Anissa A Widjaja, Sonia P Chothani, Stuart A Cook
Published 2020

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

by Ng, Benjamin, Widjaja, Anissa A., Viswanathan, Sivakumar, Dong, Jinrui, Chothani, Sonia P., Lim, Stella, Shekeran, Shamini G., Tan, Jessie, McGregor, Narelle E., Walker, Emma C., Sims, Natalie A., Schafer, Sebastian, Cook, Stuart A.
Published 2022

Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo

by Zhou J, Ng B., Ko N.S.J., Fiedler L.R., Khin E., Lim A., Sahib N.E., Wu Y., Chothani S.P., Schafer S., Bay B.-H., Sinha R.A., Cook S.A., Yen P.M.
Published 2020

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

by Lee, CQE, Kerouanton, B, Chothani, S, Zhang, S, Chen, Y, Mantri, CK, Hock, DH, Lim, R, Nadkarni, R, Huynh, VT, Lim, D, Chew, WL, Zhong, FL, Stroud, DA, Schafer, S, Tergaonkar, V, St John, AL, Rackham, OJL, Ho, L
Published 2021

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

by Widjaja, Anissa A, Viswanathan, Sivakumar, Shekeran, Shamini G, Adami, Eleonora, Lim, Wei-Wen, Chothani, Sonia, Tan, Jessie, Goh, Joyce Wei Ting, Chen, Hui Mei, Lim, Sze Yun, Boustany-Kari, Carine M, Hawkins, Julie, Petretto, Enrico, Huebner, Norbert, Schafer, Sebastian, Coffman, Thomas M, Cook, Stuart A
Published 2023

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

by Dong, Jinrui, Viswanathan, Sivakumar, Adami, Eleonora, Singh, Brijesh K, Chothani, Sonia P, Ng, Benjamin, Lim, Wei Wen, Zhou, Jin, Tripathi, Madhulika, Ko, Nicole SJ, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Wang, Mao, Lio, Pei Min, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A, Widjaja, Anissa A
Published 2022

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis.

by Widjaja, Anissa A, Singh, Brijesh K, Adami, Eleonora, Viswanathan, Sivakumar, Dong, Jinrui, D'Agostino, Giuseppe A, Ng, Benjamin, Lim, Wei Wen, Tan, Jessie, Paleja, Bhairav S, Tripathi, Madhulika, Lim, Sze Yun, Shekeran, Shamini Guna, Chothani, Sonia P, Rabes, Anne, Sombetzki, Martina, Bruinstroop, Eveline, Min, Lio Pei, Sinha, Rohit A, Albani, Salvatore, Yen, Paul M, Schafer, Sebastian, Cook, Stuart A
Published 2019

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

by Widjaja, Anissa A, Dong, Jinrui, Adami, Eleonora, Viswanathan, Sivakumar, Ng, Benjamin, Pakkiri, Leroy S, Chothani, Sonia P, Singh, Brijesh K, Lim, Wei Wen, Zhou, Jin, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Goh, Joyce, Wang, Mao, Holgate, Robert, Hearn, Arron, Felkin, Leanne E, Yen, Paul M, Dear, James W, Drum, Chester L, Schafer, Sebastian, Cook, Stuart A
Published 2022

IL-11 is a crucial determinant of cardiovascular fibrosis

by Schafer S., Viswanathan S., Widjaja A.A., Lim W.-W., Moreno-Moral A., DeLaughter D.M., Ng B., Patone G., Chow K., Khin E., Tan J., Chothani S.P., Ye L., Rackham O.J.L., Ko N.S.J., Sahib N.E., Pua C.J., Zhen N.T.G., Xie C., Wang M., Maatz H., Lim S., Saar K., Blachut S., Petretto E., Schmidt S., Putoczki T., Guimarães-Camboa N., Wakimoto H., Van Heesch S., Sigmundsson K., Lim S.L., Soon J.L., Chao V.T.T., Chua Y.L., Tan T.E., Evans S.M., Loh Y.J., Jamal M.H., Ong K.K., Chua K.C., Ong B.-H., Chakaramakkil M.J., Seidman J.G., Seidman C.E., Hubner N., Sin K.Y.K., Cook S.A.
Published 2019

Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

by Whiffin, N., Karczewski, K.J., Zhang, X., Chothani, S., Smith, M.J., Evans, D.G., Roberts, A.M., Quaife, N.M., Schafer, S., Rackham, O., Alföldi, J., Hultman, C.M., Wang, A., Wang, Q., Watts, N.A., Weisburd, B., Aguilar Salinas, C.A., Ahmad, T., Albert, C.M., Ardissino, D., Atzmon, G., Francioli, L.C., Barnard, J., Kallela, M., Beaugerie, L., Benjamin, E.J., Boehnke, M., Bonnycastle, L.L., Bottinger, E.P., Bowden, D.W., Bown, M.J., Chambers, J.C., McCarroll, S., Chan, J.C., Chasman, D., Kaprio, J., Cho, J., Chung, M.K., Cohen, B., Correa, A., Dabelea, D., Daly, M.J., Darbar, D., McCarthy, M.I., Duggirala, R., Dupuis, J., Ellinor, P.T., Kathiresan, S., Elosua, R., Erdmann, J., Esko, T., Färkkilä, M., Florez, J., Programs in Metabolism and Medical and Population Genetics, Broad Institute., McGovern, D., Department of Medicine, Harvard Medical School, Boston, MA 02115, United States., Franke, A., Getz, G., Glaser, B., Kim, B.-J., Glatt, S.J., Goldstein, D., Gonzalez, C., Groop, L., Haiman, C., McPherson, R., Hanis, C., Harms, M., Hiltunen, M., Kim, Y.J., Kirov, G., Kooner, J., Koskinen, S., O’Donnell-Luria, A.H., Krumholz, H.M., Kugathasan, S., Meigs, J.B., Kwak, S.H., Laakso, M., Lehtimäki, T., Loos, R.J.F., Lubitz, S.A., Ma, R.C.W., Marrugat, J., Mattila, K.M., Melander, O., Metspalu, A., Neale, B.M., Nilsson, P.M., Llanwarne, C., O’Donovan, M.C., Armean, I.M., Ongur, D., Orozco, L., Owen, M.J., Palmer, C.N.A., Palotie, A., Park, K.S., Pato, C., Pulver, A.E., Minikel, E.V., Rahman, N., Remes, A.M., Banks, E., Rioux, J.D., Ripatti, S., Roden, D.M., Saleheen, D., Salomaa, V., Samani, N.J., Scharf, J., Munshi, R., Schunkert, H., Shoemaker, M.B., Sklar, P., Bergelson, L., Soininen, H., Sokol, H., Spector, T., Sullivan, P.F., Suvisaari, J., Tai, E.S., Neale, B.M., Teo, Y.Y., Tiinamaija, T., Tsuang, M., Turner, D., Cibulskis, K., Tusie-Luna, T., Vartiainen, E., Watkins, H., Weersma, R.K., Wessman, M., Novod, S., Wilson, J.G., Xavier, R.J., Cook, S.A., Collins, R.L., Connolly, K.M., Covarrubias, M., Cummings, B., Daly, M.J., Donnelly, S., Farjoun, Y., Petrillo, N., Ferriera, S., Gabriel, S., Gauthier, L.D., Gentry, J., Gupta, N., Jeandet, T., Kaplan, D., Laricchia, K.M., Poterba, T., Roazen, D., Ruano-Rubio, V., Saltzman, A., Holi, M.M., Samocha, K.E., Schleicher, M., Seed, C., Solomonson, M., Soto, J., Tiao, G., Tibbetts, K., Tolonen, C., Vittal, C., Wade, G.
Published 2021

Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals (Nature Communications, (2020), 11, 1, (2523), 10.1038/s41467...

by Whiffin, Nicola, Karczewski, Konrad J., Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J., Evans, D. Gareth, Roberts, Angharad M., Quaife, Nicholas M., Schafer, Sebastian, Rackham, Owen, Alföldi, J., O’Donnell-Luria, A.H., Francioli, Laurent C., Armean, Irina M., Banks, E., Bergelson, L., Cibulskis, K., Collins, R.L., Connolly, K.M., Covarrubias, M., Cummings, B., Daly, M.J., Donnelly, S., Farjoun, Y., Ferriera, S., Gabriel, S., Gauthier, L.D., Gentry, J., Gupta, N., Jeandet, T., Kaplan, D., Laricchia, K.M., Llanwarne, C., Minikel, E.V., Munshi, R., Neale, B.M., Novod, S., Petrillo, N., Poterba, T., Roazen, D., Ruano-Rubio, V., Saltzman, A., Samocha, K.E., Schleicher, M., Seed, C., Solomonson, M., Soto, J., Tiao, G., Tibbetts, K., Tolonen, C., Vittal, C., Wade, G., Wang, A., Wang, Q., Watts, N.A., Weisburd, B., Aguilar Salinas, Carlos A., Ahmad, T., Albert, C.M., Ardissino, D., Atzmon, G., Barnard, J., Beaugerie, L., Benjamin, E.J., Boehnke, M., Bonnycastle, L.L., Bottinger, E.P., Bowden, D.W., Bown, M.J., Chambers, J.C., Chan, J.C., Chasman, D., Cho, J., Chung, M.K., Cohen, B., Correa, A., Dabelea, D., Daly, M.J., Darbar, D., Duggirala, R., Dupuis, J., Ellinor, P.T., Elosua, R., Erdmann, J., Esko, T., Färkkilä, M., Florez, J., Programs in Metabolism and Medical and Population Genetics, Broad Institute., Department of Medicine, Harvard Medical School, Boston, MA 02115, United States., Franke, A., Getz, G., Glaser, B., Glatt, S.J., Goldstein, D., Gonzalez, C., Groop, L., Haiman, C., Hanis, C., Harms, M., Hiltunen, M., Holi, M.M., Hultman, C.M., Kallela, M., Kaprio, J., Kathiresan, S., Kim, B.-J., Kim, Y.J., Kirov, G., Kooner, J., Koskinen, S., Krumholz, H.M., Kugathasan, S., Kwak, S.H., Laakso, M., Lehtimäki, T., Loos, R.J.F., Lubitz, S.A., Ma, R.C.W., Marrugat, J., Mattila, K.M., McCarroll, S., McCarthy, M.I., McGovern, D., McPherson, R., Meigs, J.B., Melander, O., Metspalu, A., Neale, B.M., Nilsson, P.M., O’Donovan, M.C., Ongur, D., Orozco, L., Owen, M.J., Palmer, C.N.A., Palotie, A., Park, K.S., Pato, C., Pulver, A.E., Rahman, N., Remes, A.M., Rioux, J.D., Ripatti, S., Roden, D.M., Saleheen, D., Salomaa, V., Samani, N.J., Scharf, J., Schunkert, H., Shoemaker, M.B., Sklar, P., Soininen, H., Sokol, H., Spector, T., Sullivan, P.F., Suvisaari, J., Tai, E. Shyong, Teo, Yik Ying, Tiinamaija, T., Tsuang, M., Turner, D., Tusie-Luna, T., Vartiainen, E., Watkins, H., Weersma, R.K., Wessman, M., Wilson, J.G., Xavier, R.J., Vawter, M.P., Cook, Stuart A., Barton, Paul J. R., MacArthur, Daniel G., Ware, James S.
Published 2022