Parkin-mediated lysine 63-linked polyubiquitination: A link to protein inclusions formation in Parkinson's and other conformational diseases?

by Lim, K.-L., Dawson, V.L., Dawson, T.M.
Published 2014

The cast of molecular characters in Parkinson's disease: Felons, conspirators, and suspects

by Lim K.L., Dawson V.L., Dawson T.M.
Published 2018

The genetics of Parkinson's disease.

by Lim K.L., Dawson V.L., Dawson T.M.
Published 2018

Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy

by Tan, J.M.M., Wong, E.S.P., Dawson, V.L., Dawson, T.M., Lim, K.-L.
Published 2014

The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin

by Yu, W.-P., Tan, J.M.M., Chew, K.C.M., Oh, T., Kolatkar, P., Venkatesh, B., Dawson, T.M., Lim, K.L.
Published 2014

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

by Sriram S.R., Li X., Ko H.S., Chung K.K.K., Wong E., Lim K.L., Dawson V.L., Dawson T.M.
Published 2018

Loss of locus coeruleus neurons and reduced startle in parkin null mice

by Von Coelln R., Thomas B., Savitt J.M., Lim K.L., Sasaki M., Hess E.J., Dawson V.L., Dawson T.M.
Published 2018

Parkin ubiquitinates the ?-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease

by Chung K.K.K., Zhang Y., Lim K.L., Tanaka Y., Huang H., Gao J., Ross C.A., Dawson V.L., Dawson T.M.
Published 2018

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

by Wong, E.S.P., Tan, J.M.M., Soong, W.-E., Hussein, K., Nukina, N., Dawson, V.I., Dawson, T.M., Cuervo, A.M., Lim, K.-L.
Published 2014

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila

by Ng, C.-H., Mok, S.Z.S., Koh, C., Ouyang, X., Fivaz, M.L., Tan, E.-K., Dawson, V.L., Dawson, T.M., Yu, F., Lim, K.-L.
Published 2014

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

by Wong, E.S.P., Tan, J.M.M., Wang, C., Zhang, Z., Tay, S.-P., Zaiden, N., Han, S.K., Dawson, V.L., Dawson, T.M., Lim, K.-L.
Published 2014

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

by West A.B., Moore D.J., Choi C., Andrabi S.A., Li X., Dikeman D., Biskup S., Zhang Z., Lim K.-L., Dawson V.L., Dawson T.M.
Published 2018

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

by Wang, C., Tan, J.M.M., Ho, M.W.L., Zaiden, N., Siew, H.W., Chew, C.L.C., Pei, W.E., Tit, M.L., Dawson, T.M., Kah, L.L.
Published 2014

Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age

by Pawlyk A.C., Giasson B.I., Sampathu D.M., Perez F.A., Lim K.L., Dawson V.L., Dawson T.M., Palmiter R.D., Trojanowski J.Q., Lee V.M.-Y.
Published 2018

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of ?-synucleinopathy

by Von Coelln R., Thomas B., Andrabi S.A., Kah L.L., Savitt J.M., Saffary R., Stirling W., Bruno K., Hess E.J., Lee M.K., Dawson V.L., Dawson T.M.
Published 2018

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: Implications for lewy body formation

by Kah, L.L., Chew, K.C.M., Tan, J.M.M., Wang, C., Chung, K.K.K., Zhang, Y., Tanaka, Y., Smith, W., Engelender, S., Ross, C.A., Dawson, V.L., Dawson, T.M.
Published 2014

Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: Implications for neuronal cell death in parkinson disease

by Chew, K.C.M., Ang, E.-T., Tai, Y.K., Tsang, F., Lo, S.Q., Ong, E., Ong, W.-Y., Shen, H.-M., Lim, K.-L., Dawson, V.L., Dawson, T.M., Soong, T.W.
Published 2014

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

by Wang, C., Chew, K.C.M., Tay, S.-P., Ho, M.W.L., Lim, K.-L., Lim, T.-M., Tsang, F., Soong, T.-W., Ko, H.S., Thomas, B., Dawson, V.L., Dawson, T.M., Troncoso, J., Pletnikova, O.
Published 2011

SEPT5_v2 is a parkin-binding protein

by Choi P., Snyder H., Petrucelli L., Theisler C., Chong M., Zhang Y., Lim K., Chung K.K.K., Kehoe K., D'Adamio L., Lee J.M., Cochran E., Bowser R., Dawson T.M., Wolozin B.
Published 2018

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

by Tan, J.M.M., Wong, E.S.P., Kirkpatrick, D.S., Pletnikova, O., Ko, H.S., Tay, S.-P., Ho, M.W.L., Troncoso, J., Gygi, S.P., Lee, M.K., Dawson, V.L., Dawson, T.M., Lim, K.-L.
Published 2014