Cross-Reactive Immunity Among Flaviviruses

by Rathore, A.P.S., St. John, A.L.
Published 2021

Immune responses to dengue virus in the skin

by Rathore, A.P.S, St John, A.L
Published 2020

Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation

by Rathore, A.P.S., Ng, M.-L., Vasudevan, S.G.
Published 2014

Japanese encephalitis virus neuropenetrance is driven by mast cell chymase

by Hsieh, J.T., Rathore, A.P.S., Soundarajan, G., St. John, A.L.
Published 2022

Maternal immunity and antibodies to dengue virus promote infection and Zika virus-induced microcephaly in fetuses

by Rathore, A.P.S., Saron, W.A.A., Lim, T., Jahan, N., St. John, A.L.
Published 2021

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

by Rathore, A.P.S., Haystead, T., Das, P.K., Merits, A., Ng, M.-L., Vasudevan, S.G.
Published 2014

Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage

by St John, A.L., Rathore, A.P.S., Raghavan, B., Ng, M.-L., Abraham, S.N.
Published 2014

The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model

by Watanabe, S., Tan, K.H., Rathore, A.P.S., Rozen-Gagnon, K., Shuai, W., Ruedl, C., Vasudevan, S.G.
Published 2014

Transcriptional profiling confirms the therapeutic effects of mast cell stabilization in a dengue disease model

by Morrison J., Rathore A.P.S., Mantri C.K., Aman S.A.B., Nishida A., St. John A.L.
Published 2020

Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance

by St. John, A.L., Rathore, A.P.S., Yap, H., Ng, M.-L., Metcalfe, D.D., Vasudevan, S.G., Abraham, S.N.
Published 2014

Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells

by Saron, W.A.A., Rathore, A.P.S., Ting, L., Ooi, E.E., Low, J., Abraham, S.N., St. John, A.L.
Published 2021

Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex

by Moreland, N.J., Tay, M.Y.F., Lim, E., Rathore, A.P.S., Lim, A.P.C., Hanson, B.J., Vasudevan, S.G.
Published 2014

Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial

by Watanabe, S., Rathore, A.P.S., Sung, C., Lu, F., Khoo, Y.M., Connolly, J., Low, J., Ooi, E.E., Lee, H.S., Vasudevan, S.G.
Published 2014

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

by Rathore, A.P.S., Paradkar, P.N., Watanabe, S., Tan, K.H., Sung, C., Connolly, J.E., Low, J., Ooi, E.E., Vasudevan, S.G.
Published 2014

Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients

by Rathore, A.P.S., Senanayake, M., Athapathu, A.S., Gunasena, S., Karunaratna, I., Leong, W.Y., Lim, T., Mantri, C.K., Wilder-Smith, A., St. John, A.L.
Published 2021

Th1-Polarized, Dengue Virus-Activated Human Mast Cells Induce Endothelial Transcriptional Activation and Permeability

by Syenina, A., Saron, W.A.A., Jagaraj, C.J., Bibi, S., Arock, M., Gubler, D.J., Rathore, A.P.S., Abraham, S.N., St John, A.L.
Published 2021

Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

by Tay, M.Y.F., Fraser, J.E., Chan, W.K.K., Moreland, N.J., Rathore, A.P., Wang, C., Vasudevan, S.G., Jans, D.A.
Published 2014

Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients

by Sung C., Wei Y., Watanabe S., Lee H.S., Khoo Y.M., Fan L., Rathore A.P.S., Chan K.W.-K., Choy M.M., Kamaraj U.S., Sessions O.M., Aw P., de Sessions P.F., Lee B., Connolly J.E., Hibberd M.L., Vijaykrishna D., Wijaya L., Ooi E.E., Low J.G.-H., Vasudevan S.G.
Published 2018