Correlation of Low CD4+ Counts with High Dental Caries Prevalence in Children Living with Perinatal HIV/AIDS Undergoing Antiretroviral Therapy

• Main Authors: Alexander Patera Nugraha, -, Mario Powa Mensana, -, Bagus Soebadi, -, Dominicus Husada, -, Erwin Astha Triyono, -, Remita Adya Prasetyo, -, Diah Savitri Ernawati, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Associacao de Apoio a PesquisaemSaudeBucal - APESB 2019
• Subjects: R Medicine (General); RJ Pediatrics
• Online Access: https://repository.unair.ac.id/114486/2/C15-Similarity.pdf; https://repository.unair.ac.id/114486/4/C15-Artikel.pdf; https://repository.unair.ac.id/114486/7/C15-Peer%20Review.pdf; https://repository.unair.ac.id/114486/; https://www.researchgate.net/publication/336211778_Correlation_of_Low_CD4_Counts_with_High_Dental_Caries_Prevalence_in_Children_Living_with_Perinatal_HIVAIDS_Undergoing_Antiretroviral_Therapy; http://dx.doi.org/10.4034/PBOCI.2019.191.119
• Institution: Universitas Airlangga

Objective: To investigate the correlation Cluster of Differentiation 4⁺ (CD4⁺) counts with a high prevalence of dental caries in Children Living with Perinatal Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (CLWPHA). Material and Methods: An analytical observational research with a cross-sectional design was conducted at Tertiary General Hospital, Surabaya, Indonesia. Randomized total sampling consisted of 29 CLWPHA 1-12 years old at outpatient ward Infectious Disease Intermediate Unit (UPIPI) Tertiary General Hospital Doctor Soetomo Surabaya. Demographic details and recent CD4⁺ counts obtained from medical records. Decayed, missing, filled teeth (dmft) in primary teeth and DMFT in permanent teeth index were used. Pearson's and Spearman's Correlation test (p<0.05) were performed Results: Dental caries prevalence was 86.2%; meanwhile, the dmft/DMFT index score found were high (8.2 / 6.3). CD4⁺ count and caries showed significant correlation (r=-0.394, p<0.05). Tooth brushing frequency with caries showed a significant correlation (r=-0.419, p<0.05). Antiretroviral (ARV) therapy and caries showed an insignificant negative correlation (p<0.05) Conclusion: The high prevalence of dental caries in CLWPHA correlated with low CD4⁺ counts.