The Anti-Inflammatory Effect of ACE-I/ARBs Drug on hs-CRP and HDL-Cholesterol in CKD Patient
Chronic kidney disease (CKD) is progressive disease that closely related to the chronic inflammatory process. Angiotensin-Converting Enzyme Inhibitor (ACE-I)/Angiotensin Receptor Blockers (ARBs) is the main therapy in the management of CKD, based on the recent sudies stated that this drug have ple...
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Main Authors: | , , , |
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Format: | Article PeerReviewed |
Language: | English English English |
Published: |
Medico Legal Society
2021
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Subjects: | |
Online Access: | https://repository.unair.ac.id/126354/1/27.%20The%20Anti-Inflammatory%20Effect%20of%20ACE-IARBs%20Drug%20on%20hs-CRP%20and%20HDL-Cholesterol%20in%20CKD%20Patient_Indian%20Journal%20of%20Forensic%20Medicine%20%26%20Toxicology%202021.pdf https://repository.unair.ac.id/126354/2/karil%2027.pdf https://repository.unair.ac.id/126354/3/27.%20Turnitin.pdf https://repository.unair.ac.id/126354/ https://medicopublication.com/index.php/ijfmt/article/view/15878 https://doi.org/10.37506/ijfmt.v15i3.15878 |
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Institution: | Universitas Airlangga |
Language: | English English English |
Summary: | Chronic kidney disease (CKD) is progressive disease that closely related to the chronic inflammatory process.
Angiotensin-Converting Enzyme Inhibitor (ACE-I)/Angiotensin Receptor Blockers (ARBs) is the main
therapy in the management of CKD, based on the recent sudies stated that this drug have pleiotropic effects
as anti-inflammation.The aim of this study is tosee the interaction of hs-CRP and HDL-Cholesterol to prove
the role of ACE-I/ARBs as an anti-inflammatory treatment for CKD patient. In this study we compared hsCRP, HDL Cholesterol and HDL Cholesterol /hs-CRP ratio levels in CKD patients who consumeand do not
consumeACE-I/ARBs. Forty eight samples of CKD patients were taken randomly and then separated into
two group based on their consumption of ACE-I/ARBs, each group have 24 samples.There were significantly
different of mean of hs-CRP, HDL Cholesterol, and HDL Cholesterol/hs-CRP ratio between group, the mean
concentration of hs-CRP in the ACE-I/ARBs group was significantly lower than in non-ACE-I/ARBs group
(1,48±0,81 vs 4,19±4,02; P= 0.038),the mean of HDL (48,95±13,05vs 41,50±12,31; P= 0,048).There were
negative correlation between HDL Cholesterol and hs-CRP, positive correlation between HDL Cholesterol/
hs-CRP ratio and eGFR.This result indicate that hs-CRP and HDL-Cholesterol monitoring very important
in CKD patient. |
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