Penentuan Isoform Sitokrom P450 Potensial pada Metabolisme Obat dengan Model Obat Gliklazid

• المؤلف الرئيسي: Suharjono
• التنسيق: مقال PeerReviewed
• اللغة: English; Indonesian; Indonesian
• منشور في: Pengurus Pusat Ikatan Apoteker Indonesia 2006
• الموضوعات: RS Pharmacy and materia medica
• الوصول للمادة أونلاين: http://repository.unair.ac.id/51734/1/BUKTI%20C-18%20JFI%20PENENTUAN%20CYP450%20GLIKLAZIDE%20COVER%20DAN%20TOC%20REPOSITORI.pdf; http://repository.unair.ac.id/51734/2/BUKTI%20C-18%20.compressed.pdf; http://repository.unair.ac.id/51734/3/rev%20c18.pdf; http://repository.unair.ac.id/51734/; http://jfionline.org/index.php/jurnal/article/view/68

With the advancement of molecular biology techniques and extended use of human liver microsomes (HLM), we have known the specific isoform of cytocrome P450 (CYP450) involved in human drug metabolisms. The specific isoform need certain physicochemistry characteristic of the drug to be metabolized, e....