Physical Characteristics of Liposomal Formulation Dispersed in HPMC Matrix and Freeze-Dried Using Maltodextrin and Mannitol as Lyoprotectant

• Main Authors: Raditya Weka Nugraheni, Dwi Setyawan, NIDN. 0030117104, Helmy Yusuf, NIDN. 0015077901
• 格式: Article PeerReviewed
• 語言: English; English; English
• 出版: Tabriz University of Medical Sciences 2017
• 主題: R Medicine; RS Pharmacy and materia medica
• 在線閱讀: http://repository.unair.ac.id/85764/6/C-06.pdf; http://repository.unair.ac.id/85764/2/Physical%20Characteristics%20of%20Liposomal%20Formulation%20Dispersed%20in%20HPMC%20Matrix%20and%20Freeze-Dried%20Using%20Maltodextrin%20and%20Mannitol%20as%20Lyoprotectant.pdf; http://repository.unair.ac.id/85764/5/C-06%20Rev.pdf; http://repository.unair.ac.id/85764/; https://ps.tbzmed.ac.ir/Article/PHARM_19430_20170618185504

Background: The present study aims to design formulation of liposomes that are well-preserved during freeze-drying. The combination of Hydroxy Propyl Methyl Cellulose (HPMC) as dispersion matrix and lyoprotectants; maltodextrin or mannitol, was employed to prevent aggregation and/or recrystallizatio...