EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK LARUT ETANOL HERBA SAMBILOTO (Andrographis paniculata (Burm.f.) Ness) DAN DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr) TERSTANDAR ANDROGRAFOLID DAN KUERSETIN PADA TIKUS DIABETES DIINDUKSI ALOKSAN
Exploration of medicinal plant combination could be an alternative way for developing medicinal plants in order to provide better result or benefits in disease therapy. Andrographis paniculata (Burm. f.) Ness and Gynura procumbens (Lour.) Merr are two medicinal pla...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/130610/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=71036 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Exploration of medicinal plant combination could be an alternative way
for developing medicinal plants in order to provide better result or benefits in
disease therapy. Andrographis paniculata (Burm. f.) Ness and Gynura
procumbens (Lour.) Merr are two medicinal plants that already well known for
those hypoglycemic activity. Hopefully, the combination of both extracts could
exhibit better effect than those single extract administration. The aim of this study
was to evaluate the hypoglycemic effect of A. paniculata ethanolic extract
(APEE) and G. procumbens ethanolic extract (GPEE) combination in alloxan
induced hyperglycemic rats.
The powder of A. paniculata herbs and G. procumbens leaves were
extracted by maceration using ethanol 70% respectively. Phytochemical analysis
of andrographolide contained in APEE and quercetin contained in GPEE were
performed by TLC-densitometry using stationery phase silica gel F254 and
mobile phase chloroform-ethyl acetic-methanol-acetic acid (7:2:0.5:0.5 v/v/v).
Hyperglycemic condition in rats was induced with a single dose of 150 mg/kg
BW alloxan intraperitoneally. The rats were orally administrated with several kind
of dosage APEE:GPEE (300:37.5 |
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