Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) Smith against oxidative stress on paraquat-induced parkinsonism in rats

• Main Authors: Farah Wahida Ibrahim, Umi Noraashikin Zainudin, Mazlyzam Abdul Latif, Asmah Hamid
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2018
• Online Access: http://journalarticle.ukm.my/12503/1/10%20Farah%20Wahida%20Ibrahim.pdf; http://journalarticle.ukm.my/12503/; http://www.ukm.my/jsm/malay_journals/jilid47bil10_2018/KandunganJilid47Bil10_2018.htm
• Institution: Universiti Kebangsaan Malaysia

Zingiber zerumbet has been traditionally used as an anti-inflammation and antioxidant agent. The present study investigates the neuroprotective effects of ethyl acetate extract of Z. zerumbet against oxidative stress on paraquat (PQ)-induced Parkinsonism in rats. Forty male Sprague-Dawley rats were divided into five groups: Negative control (normal saline), positive control (N-acetylcysteine, NAC 20 mg/kg + PQ 10 mg/kg), PQ only, 200 mg/kg Z. zerumbet + PQ and 400 mg/kg Z. zerumbet + PQ. The extract was given orally for 19 consecutive days and PQ was administered intraperitoneally on day 8-12th of the treatment regime. Both serum and fresh brains containing substantia nigra (SN) region were taken for biochemical and histological analysis. Administration of both 200 and 400 mg/kg ethyl acetate Z. zerumbet extracts to the PQ-treated groups have resulted in: Decreased levels of MDA and PC in the SN homogenates; and increased SOD, GPx; and CAT activities in the SN and serum. Overall, ethyl acetate extract of Z. zerumbet reduced oxidative stress in the SN of PQ-induced neuronal damages, therefore, has the potential to be developed as a preventive agent for neurodegenerative disorders caused by environmental toxins.