Optimization of effervescent tablet-assisted dispersive liquid-liquid microextraction with central composite design for preconcentration of stimulant drug

• Main Authors: Nurliyana Tazulazhar, Loh, Saw Hong, Marinah Mohd Ariffin, Wan Mohd Afiq Wan Mohd Khalik
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2021
• Online Access: http://journalarticle.ukm.my/16397/1/12.pdf; http://journalarticle.ukm.my/16397/; https://www.ukm.my/jsm/malay_journals/jilid50bil1_2021/KandunganJilid50Bil1_2021.html
• Institution: Universiti Kebangsaan Malaysia

The extraction efficiency of stimulant drug, namely caffeine, was investigated using a 23 central composite design. The values of optimum extraction condition were set at 468 µL of 1-dodecanol, 1 piece of effervescent tablet, and 22 °C of extraction temperature. An enrichment factor was calcul...