Microwave vs. reflux synthesis of bis-thiourea derivative: yield optimization, crystallographic understanding and optical sensing potential

• Main Authors: Hasanain Salah Naeem, Jaber, Israa, Suhaila Sapari, Fazira Ilyana Abdul Razak, Rudaini, Bilal Majid, Nurul Hidayah Abd Razak, Asmaa, Soheil Najm, Siti Aishah Hasbullah
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2024
• Online Access: http://journalarticle.ukm.my/24361/1/SL%2017.pdf; http://journalarticle.ukm.my/24361/; https://www.ukm.my/jsm/english_journals/vol53num8_2024/contentsVol53num8_2024.html
• Institution: Universiti Kebangsaan Malaysia

A new bis-thiourea (BT) derivative was successfully synthesized using both conventional reflux and microwave irradiation methods. The microwave irradiation reaction yielded a greater percentage yield of 73%, while the reflux heating yielded only 44%. The microwave irradiation procedure takes a minimum of 10 min to complete, in contrast to the reflux heating method, which takes 24 h. The compound was characterised using a variety of spectroscopic techniques, including UVVis, FTIR, nuclear magnetic resonance (1 H-NMR and 13C-NMR), and single crystal X-ray crystallography (XRC). It shows that BT has a high ability to form hydrogen bonds of both intermolecular and intramolecular types, as demonstrated by X-ray crystallography and DFT calculations. In addition, this research provides insights into the possible uses of BT in coordination chemistry involving metal ions, such as a copper ions. Through the use of density-functional theory (DFT) and UV-Vis investigations, it is envisaged that the BT compound has a strong tendency to form stable copper ion complexes. This is supported by the optimal energy value E(UB3LYP) observed for the Cu(II) complex.