Anti N-Methyl-D-Aspartate Receptor encephalitis with ovarian teratoma: a dilemma in diagnosis

• Main Authors: Lee, CL, Aini Amelia Zainuddin, Abdul Kadir Abdul Karim, Yulianty Arifuddin, Law, Zhee Kang, Md. Isa N, Nor Azlin Mohamed Ismail
• Format: Article
• Language: English
• Published: Faculty of Medicine, UKM Medical Centre 2016
• Online Access: http://journalarticle.ukm.my/9841/1/15._Lee_et_al..pdf; http://journalarticle.ukm.my/9841/; http://jsurgacad.com/toc/6/1
• Institution: Universiti Kebangsaan Malaysia

We report a rare case of altered mental status in a young patient with immature ovarian teratoma. A 22-year-old woman presented with seizures, hallucination, amnesia and orofacial dyskinesia. Examination and investigation revealed an ovarian massand asalphing-oophorectomy was performed. The histopathological examination result showed an immature teratoma grade 2 with thepresence of immature primitive glial tissue. Her CSF N-Methyl-D-Aspartic acid receptor (Anti-NMDAR) antibodytest was positive. N-Methyl-D-Aspartic acid receptor antibody associated limbic encephalitis is an autoimmune antibody-mediated neuropsychiatric disorder. Resection of the tumour and immunotherapy resulted in full recovery.