Erythroxylum cuneatum regulates the cell adaptation through the ERK 1/2 signalling in addictive morphine-induced cell line

• Main Authors: Noor Azuin, Suliman, Mohamad Aris, Mohd Moklas, Che Norma, Mat Taib
• Format: Article
• Language: English
• Published: 2020
• Subjects: R Medicine (General)
• Online Access: http://eprints.unisza.edu.my/7304/1/FH02-FP-20-44226.pdf; http://eprints.unisza.edu.my/7304/
• Institution: Universiti Sultan Zainal Abidin

Introduction: Chronic treatment of morphine stimulates prolonged activation of the µ-opioid receptor, causes the stimulation of cellular adaptation through ERK 1/2 pathway. The abrupt termination of chronic morphine was observed to cause withdrawal activity through the same pathway. The alkaloi...