Box–Behnken design based development of UV-reversed phase high performance liquid chromatographic method for determination of ascorbic acid in tablet formulations

• Main Authors: Azmi, Syed Najmul Hejaz, Al Hoqani, Umaima, Obaid Said Al Mamari, Juhaina, Mohamed Salim Al Mamari, Buthaina, Sultan Ali Rashid Al Jassasi, Balaqis, Saleh Saif Al Rubaiai, Aziza, Rahman, Nafisur, Nasir, Mohd, Haque, Sk Manirul, Khan, Shah Alam, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
• Format: Article
• Language: English
• Published: MDPI 2022
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/101225/7/101225_Box%E2%80%93Behnken%20design%20based%20development.pdf; http://irep.iium.edu.my/101225/; https://www.mdpi.com/2297-8739/9/11/361/htm
• Institution: Universiti Islam Antarabangsa Malaysia

A simple, sensitive, accurate and inexpensive UV-reversed-phase high-performance liquid chromatographic method was developed for the determination of ascorbic acid in tablet formulations. The method was based on the separation of ascorbic acid using a mobile phase of an acetonitrileNaH2PO4 -H3PO4...