On-site whole-genome sequencing of SARS-COV-2 reveals C3037T mutation in patient with Atrioventricular Nodal Reentry Tachycardia (AVNRT)

• Main Authors: Zainulabid, Ummu Afeera, Mohd Said, Mohd Ridzuan, Ahmad, Hajar Fauzan
• Format: Article
• Language: English; English; English
• Published: Elsevier 2023
• Subjects: RC Internal medicine; RC111 Infectious and Parasitic Diseases; RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
• Online Access: http://irep.iium.edu.my/105322/7/105322_On-site%20whole-genome.pdf; http://irep.iium.edu.my/105322/13/105321_A%20case%20series%20Of%20Shewanella%20algae%20bacteremia%20with%20different%20outcomes_WOS.pdf; http://irep.iium.edu.my/105322/18/105322_On-site%20whole%20genome%20sequencing%20of%20SARS-COV-2%20reveal%20C3037T_WOS.pdf; http://irep.iium.edu.my/105322/; https://www.sciencedirect.com/science/article/pii/S1201971223003739
• Institution: Universiti Islam Antarabangsa Malaysia

The spike protein of the SARS-CoV-2 virus targets the human cell receptor of angiotensin-converting enzyme (ACE2), including the myocardium and heart's conduction system. Patients diagnosed with COVID-19 have also been found to exhibit cardiac arrhythmia. Here, a whole-genome sequencing analysis using long-read sequencing was proposed to evaluate the virus genome in a patient who presented with AVNRT as a main presentation of COVID-19.