Presence of allelic loss and PTEN mutations in malignant gliomas from Malay patients

• Main Authors: Zainuddin, Norafiza, Jaafar, Hasnan, Isa, Mohd. Nizam, Abdullah, Jafri Malin
• Format: Article
• Language: English
• Published: Malaysian Medical Associations 2004
• Subjects: RC254 Neoplasms. Tumors. Oncology (including Cancer); RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
• Online Access: http://irep.iium.edu.my/31130/1/MJM_Malignant_Gliomas.pdf; http://irep.iium.edu.my/31130/; http://www.mma.org.my/Publications/MedicalJournalofMalaysia/tabid/69/Default.aspx
• Institution: Universiti Islam Antarabangsa Malaysia

Loss of heterozygosity (LOH) on several loci and mutations on PTEN tumor suppressor gene (10q23.3) occur frequently in sporadic gliomas. We have performed polymerase chain reaction (PCR)-LOH analysis using microsatellite markers and single-stranded conformational polymorphism (SSCP) analysis to dete...