A review on the formulation and analysis of anti-diabetic agent: Gliclazide

• Main Authors: Helal Uddin, A.B.M., Alaama, Mohammed, Abdualkader, Abdualrahman Mohammed, Awang, Mohamed, Ahmed, Qamar Uddin, Abbas, Syed Atif
• Format: Article
• Language: English
• Published: Trans Tech Publications, Switzerland 2013
• Subjects: QD Chemistry; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/32319/1/Glaclizide-paper.pdf; http://irep.iium.edu.my/32319/; http://www.scientific.net/AMR.810.159
• Institution: Universiti Islam Antarabangsa Malaysia

Gliclazide is a second generation sulfonylurea, which is used as antidiabetics drug. It is orally administrated and used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) and has duration of action of 12 h or more. Beside its hypoglycaemic effects, gliclazide was reported to have many other important effects, such as: suppression of platelet functions, antithrombotic actions, decreased the production of tumour necrosis factor (TNF) á by endothelial cells and other effects. The unique activities of gliclazide has open a new avenue for the drug development research. This work is aimed to provide comprehensive information about gliclazide and its current research activities.