Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats

• Main Authors: Kaleem, Mohammed, Medha, P., Ahmed, Qamar Uddin, Asif, Mohd S., Bano, Bilqees
• Format: Article
• Language: English
• Published: Singapore Medical Association 2008
• Subjects: Q Science (General)
• Online Access: http://irep.iium.edu.my/40987/1/Beneficial_effects_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf; http://irep.iium.edu.my/40987/; http://smj.sma.org.sg/4910/4910a7.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Introduction: The present study investigated the possible therapeutic effects of Annona squamosa (A. squamosa) extract on certain biochemical markers in streptozotocin (STZ) -induced diabetes mellitus in rats. Methods: The effects of an aqueous extract of A. squamosa leaves on blood glucose, insulin, C-peptide, albumin, albumin/globulin ratio, urea, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups. Results: Oral administration of A. squamosa (300 mg/kg) aqueous extract to diabetic rats for 30 days significantly reduced blood glucose, urea, uric acid and creatinine, but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels. Conclusion: The present results shown that A. squamosa extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats.