Silencing endogenous mutant P53 Using Sirna Induces P73-Mediated Apoptosis in Human Head And Neck Squamous Cell Carcinoma

• Main Authors: Arief Ichwan, Solachuddin Jauhari, Taher, Muhammad, Masa-Aki, Ikeda
• Format: Conference or Workshop Item
• Language: English
• Published: 2011
• Subjects: RK Dentistry
• Online Access: http://irep.iium.edu.my/4141/1/Abstract_siRNA-p73_MSPP2011.pdf; http://irep.iium.edu.my/4141/
• Institution: Universiti Islam Antarabangsa Malaysia

Loss of p53 tumor suppressor function is a common event in numerous types of human cancer including Head and Neck Squamous Cell Carcinoma (HNSCC). p73, a member of the p53 family gene has striking structural homology and similar interrelated functions with the p53 gene; transactivate p53 responsive...