In vitro cytotoxic activity of ferula assafoetida on osteosarcoma cell line (Hos crl)

Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. Th...

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Bibliographic Details
Main Authors: Mohd Shafri, Mohd Affendi, Yusof, Fathin Athirah, Md Zain, Ahmad Zulkarami
Format: Article
Language:English
Published: Universiti Teknologi Malaysia 2015
Online Access:http://irep.iium.edu.my/47438/1/5994-16777-1-SM.pdf
http://irep.iium.edu.my/47438/
http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/5994
http://dx.doi.org/10.11113/jt.v77.5994
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Institution: Universiti Islam Antarabangsa Malaysia
Language: English
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Summary:Ferula assafoetida is a herb that has been used traditionally to treat rheumatism, broken bones and stomach illness. The aim of this research is to study the cytotoxicity of F. assafoetida as an anti-cancer agent. Briefly, resin of F. assafoetida was macerated with ethanol or methanol for 3 days. The mixtures were then filtered, concentrated and dried. The cytotoxicity of extracts on an osteosarcoma cell line, HOS CRL, was determined using MTT assay method. The results were analysed with Tukey’s test (p<0.05) showed that F. assafoetida extract has cytotoxic effect which is dependent on the type of solvent (methanol > ethanol) and concentration (higher methanolic content > lower methanolic content). In conclusion, extracts of Ferula assafoetida might possess cytotoxic activity which could be useful to be developed for an anti-cancer treatment.