Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats

• Main Authors: Ismail, Azlini, Mohamed, M., Sulaiman, Siti Amrah, Wan Ahmad, W. A. N.
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2013
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/48151/1/716532.pdf; http://irep.iium.edu.my/48151/; http://dx.doi.org/10.1155/2013/716532
• Institution: Universiti Islam Antarabangsa Malaysia

Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100 mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100 mg/kg AESP caused mild bradycardia (