Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model

• Main Authors: Salama, Mohamed, Elhussiny, Mahmoud, Magdy, Alshimaa, Omran, Ahmed G., Alsayed, Aziza, Ashry, Ramy, Mohamed, Wael Mohamed Yousef
• Format: Article
• Language: English; English; English
• Published: Springer Nature 2018
• Subjects: QP Physiology; R Medicine (General)
• Online Access: http://irep.iium.edu.my/58970/30/58970_A%20Survey%20of%20schema%20matching%20research_complete.pdf; http://irep.iium.edu.my/58970/13/58970_Dual%20mTORC1_scopus.pdf; http://irep.iium.edu.my/58970/24/58970_Dual%20mTORC1-mTORC2%20blocker%20as%20a%20possible%20therapy_WoS.pdf; http://irep.iium.edu.my/58970/; https://link.springer.com/article/10.1007%2Fs11011-017-0137-7
• Institution: Universiti Islam Antarabangsa Malaysia

Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau. A suggested therapeutic strategy for tauopathy is to induce autophag...