Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar

• Main Authors: Mohamed Sideek, Mohamed Arshad, Teia, Abdulrahman, Kopecki, Zlatko, Cowin, Allison J., Gibson, Mark A.
• Format: Article
• Language: English; English
• Published: Springer Netherlands 2016
• Subjects: RB Pathology
• Online Access: http://irep.iium.edu.my/62197/1/LTBP-2%20Fibrotic%20Paper%20-%20J%20Mol%20Hist.pdf; http://irep.iium.edu.my/62197/7/62197_Co-localization%20of%20LTBP-2%20with%20FGF-2%20in%20fibrotic_scopus.pdf; http://irep.iium.edu.my/62197/; http://download.springer.com/static/pdf/221/art%253A10.1007%252Fs10735-015-9645-0.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs10735-015-9645-0&token
• Institution: Universiti Islam Antarabangsa Malaysia

We have recently shown that Latent transforming growth factor-beta 1 binding protein-2 (LTBP-2) has a single high-affinity binding site for fibroblast growth factor-2 (FGF-2) and that LTBP-2 blocks FGF-2 induced cell proliferation. Both proteins showed strong co-localisation within keloid skin from...