Computational quest for finding potential Ebola VP40 inhibitors: a molecular docking study

• Main Authors: Mohamad Yussoff, Mohamad Ariff, Abdul Hamid, Azzmer Azzar, Abd Hamid, Shafida, Abd Halim, Khairul Bariyyah
• Format: Article
• Language: English; English
• Published: Faculty of Science and Technology, Universiti Kebangsaan Malaysia 2020
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/83780/1/Sains%20Malaysiana-Ariff.pdf; http://irep.iium.edu.my/83780/7/83780_Computational%20quest%20for%20finding%20potential%20Ebola%20VP40%20inhibitors.pdf; http://irep.iium.edu.my/83780/; http://www.ukm.edu.my/jsm/pdf_files/SM-PDF-49-3-2020/ARTIKEL%208.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Interaction of Ebola virus matrix protein VP40 with RNA is crucial in the early infection stage to facilitate the transcription of the viral gene. Thus, VP40 is a promising target to inhibit the Ebola virus from spreading. This study aims to identify and optimize ligands that can potentially block...