Effect of ultrasonic waves on polymorphism and crystal size distributions of mefenamic acid

• Main Authors: Abdul Mudalip, Siti Kholijah, Sezali, N A, Abu Bakar, Mohd Rushdi
• Format: Conference or Workshop Item
• Language: English; English
• Published: IOP Publishing Ltd. 2020
• Subjects: QD Chemistry; RS Pharmacy and materia medica; RS192 Materia Medica-Pharmaceutical Technology; TP Chemical technology; TP155 Chemical engineering
• Online Access: http://irep.iium.edu.my/87487/7/87487_Effect%20of%20ultrasonic%20waves%20on%20polymorphism_SCOPUS.pdf; http://irep.iium.edu.my/87487/8/87487_Effect%20of%20ultrasonic%20waves%20on%20polymorphism.pdf; http://irep.iium.edu.my/87487/; https://iopscience.iop.org/article/10.1088/1757-899X/991/1/012118/pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Crystallization of pharmaceutical compound that have different polymorphic forms and broad crystal size distributions remain major challenge in industry. In this present work, the potential of ultrasonic intensifications on crystallization of mefenamic acid polymorph is investigated. The effect of sonication times (5 min – 30 min) and ultrasonic powers (153.3 – 766.7 Watt) at frequency of 65 kHz on polymorphic form and crystals size distributions (CSDs) of mefenamic acid crystals during cooling crystallization were investigated using One-Factor-At-a-Time method (OFAT). The polymorphic form, CSD and shape were determined using Fourier transform infrared spectroscopy (FTIR), Malvern Mastersizer, optical microscope and X-ray diffractometry, respectively. It was found that ultrasonic power of 766.7 Watt and 30 min of sonication time produce plate-shaped crystals with the narrow CSD. The polymorph was consistent with Form I. The findings justify the suitability of ultrasonic waves to produced platelike mefenamic acid Form I crystals with narrow CSD.