Insights into In Vitro Adaptation of EV71 and Analysis of Reduced Virulence by In Silico Predictions

• Main Authors: Koh, Jia Xuen *, Masomian, Malihe *, Mohd Ishtiaq, Anasir, Ong, Seng Kai *, Poh, Chit Laa *
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: QR Microbiology; RA Public aspects of medicine; RS Pharmacy and materia medica
• Online Access: http://eprints.sunway.edu.my/2734/1/Ong%20Seng%20Kai_Insights%20into%20In%20Vitro%20Adaptation%20of%20EV71.pdf; http://eprints.sunway.edu.my/2734/; https://doi.org/10.3390/vaccines11030629
• Institution: Sunway University

EV-A71 is a common viral pathogen that causes hand, foot and mouth disease. It is a single-stranded RNA virus that has a low fidelity RNA polymerase and, as a result, spontaneous mutations frequently occur in the EV-A71 genome. The mutations within the genome give rise to quasispecies within the vir...