Increased body mass index is associated with sarcopenia and related outcomes

• Main Authors: Nurul Nabilah, Akmal Hashim, Sumaiyah, Mat, Myint, Phyo K, Kioh, Sheng Hui, Delibegovic, Mirela, Chin, Ai-Vyrn, Shahrul, Bahyah Kamaruzzaman, Noran, Naqiah Hairi, Khoo, Selina, Tan, Maw Pin *
• Format: Article
• Published: Wiley 2023
• Subjects: QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2760/; https://doi.org/10.1111/eci.13874
• Institution: Sunway University

Sarcopenia, characterized by loss of lean body mass, muscle strength and physical performance in older adults, is a geriatric syndrome. Physical inactivity, increasing sedentary behaviour, as well as poor nutritional and health status enhance the progressive decline of muscle function and strength among older adults. Previous studies have highlighted being underweight as an important risk factor for sarcopenia which may be compounded by progressive loss of body mass and muscle strength during ageing. However, total body fat is known to increase with age. Sarcopenia and excessive adiposity may, therefore, share similar pathophysiology since both involve low-grade inflammation with accelerated muscle catabolism.