Aggregatibacter actinomycetemcomitans as the Aetiological Cause of Rheumatoid Arthritis: What Are the Unsolved Puzzles?

• Main Authors: Looh, Sung Cheng, Soo, Zoey May Pheng, Wong, Jia Jia, Yam, Hok Chai, Chow, Sook Khuan, Hwang, Jung Shan *
• Format: Article
• Language: English
• Published: Elsevier 2022
• Subjects: QR Microbiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2981/1/Hwang%20Jun%20Shan_Aggregatibacter%20actinomycetemcomitans%20as%20the%20aetiological%20cause%20of%20rheumatoid%20arthritis.pdf; http://eprints.sunway.edu.my/2981/; https://doi.org/10.3390/toxins14010050
• Institution: Sunway University

Leukotoxin A (LtxA) is the major virulence factor of an oral bacterium known as Aggregatibacter actinomycetemcomitans (Aa). LtxA is associated with elevated levels of anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) patients. LtxA targets leukocytes and triggers an influx of...