Spectrophotometric method for hydroquinone determination in skin whitening products / Nur Farehah Azhar
Hydroquinone is belongs to phenolic aromatic organic compound with the chemical formula of C6H4 (OH)2. Hydroquinone is commonly used as skin whitening agent in cosmetic products. It has the ability to make the skin appear fairer. Hence, the amount of hydroquinone in cosmetic products must be anal...
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| Format: | Student Project |
| Language: | English |
| Published: |
Faculty Of Applied Sciences
2019
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| Subjects: | |
| Online Access: | http://ir.uitm.edu.my/id/eprint/25371/1/PPb_NUR%20FAREHAH%20AZHAR%20AS%20C%2019_5.PDF http://ir.uitm.edu.my/id/eprint/25371/ |
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| Institution: | Universiti Teknologi Mara |
| Language: | English |
| Summary: | Hydroquinone is belongs to phenolic aromatic organic compound with the chemical
formula of C6H4 (OH)2. Hydroquinone is commonly used as skin whitening agent in
cosmetic products. It has the ability to make the skin appear fairer. Hence, the
amount of hydroquinone in cosmetic products must be analyzed. The presence of
hydroquinone that exceeds the permitted level of 2 % in cosmetic products is toxic
for human. Therefore, a sensitive, accurate, simple, rapid and low cost analytical
method is required for the determination of hydroquinone. The spectrophotometric
method has been proposed for the quantitative analysis of hydroquinone. The
calibration curve was linear from 2 mg L-1 to 12 mg L-1 of hydroquinone with a
regression coefficient (R2) of 0.9999. The limit of detection (LOD) obtained was
0.25 mg L-1 . The precisions in terms of relative standard deviation (RSD) were 4.44
%, 2.22 % and 0.00 % for 2 mg L-1 hydroquinone in consecutive three days.
Meanwhile, the RSD were 0.86 %, 2.52 % and 1.71 % for 5 mg L-1.Lastly, for
concentration of 8 mg L-1 the RSD were 0.00 %, 1.05 % and 0.53 %. The range of
recovery achieved for 2 and 4 mg L-1 of hydroquinone standard solution in the skin
whitening product were 99.18 % and 94.25 % respectively. The all tested skin
whitening products contain hydroquinone below 2 % except for one product which is
Collagen Plus (night cream) that slightly exceed the limit with 2.06 %. So, it can be
concluded that this proposed method is accurate, simple, fast, low cost and has a
potential to be an alternative method for routine analysis of hydroquinone in
cosmetic samples. |
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