Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali

• Main Author: Razali, Sharipah
• Format: Thesis
• Language: English
• Published: 2012
• Subjects: Materia medica
• Online Access: http://ir.uitm.edu.my/id/eprint/39614/1/39614.pdf; http://ir.uitm.edu.my/id/eprint/39614/
• Institution: Universiti Teknologi Mara

Solid dispersion utilizing superdisintegrants and effervescent agents was met with slow matrix disaggregation during dissolution and effervescence loss during storage, thereby delaying drug dissolution. This study employed electrolyte as alternative dispersant of fast-release matrix prepared using s...