Development of an alkaloid–pyrone annulation: synthesis of pleiomaltinine

• Main Authors: Kam, T.S., Ziegler, R.E., Tan, S.J., Porco Jr., J.A.
• Format: Article
• Language: English
• Published: Wiley-VCH Verlag 2012
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/10389/1/Development_of_an_Alkaloid.pdf; http://eprints.um.edu.my/10389/
• Institution: Universiti Malaya

Methodology for the synthesis of alkaloid-pyrones using a novel pyrone annulation of β–carbolines and indoles with 3-siloxy-4-pyrones is reported. The approach has enabled semisynthesis of the unprecedented alkaloid-pyrone pleiomaltinine from the plant-derived indole-alkaloid pleiocarpamine.