Incomplete cellular reprogramming of colorectal cancer cells elicits an epithelial/mesenchymal hybrid phenotype

• Main Authors: Hiew, Michele Sook Yuin, Cheng, Han Ping, Huang, Chiu Jung, Chong, Kowit Yu, Cheong, Soon Keng, Choo, Kong Bung, Kamarul, Tunku
• Format: Article
• Published: BMC 2018
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/21893/; https://doi.org/10.1186/s12929-018-0461-1
• Institution: Universiti Malaya

Background: Induced pluripotency in cancer cells by ectopic expression of pluripotency-regulating factors may be used for disease modeling of cancers. MicroRNAs (miRNAs) are negative regulators of gene expression that play important role in reprogramming somatic cells. However, studies on the miRNA...