One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives

One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives

An environmentally benign, simple, and efficient procedure has been developed for the one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives by the reaction of the variety of aryl-aldehydes, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and urea in the presence of catalyti...

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Main Authors: Hamid, Sharifah Bee Abd, Titinchi, Salam J.J., Abbo, Hanna, Khaligh, Nader Ghaffari
Format: Article
Published: Taylor & Francis 2018
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/21965/
https://doi.org/10.1080/10406638.2016.1194298
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Institution: Universiti Malaya
id my.um.eprints.21965
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spelling my.um.eprints.219652019-08-20T03:30:17Z http://eprints.um.edu.my/21965/ One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives Hamid, Sharifah Bee Abd Titinchi, Salam J.J. Abbo, Hanna Khaligh, Nader Ghaffari Q Science (General) QD Chemistry An environmentally benign, simple, and efficient procedure has been developed for the one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives by the reaction of the variety of aryl-aldehydes, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and urea in the presence of catalytic amount of poly(N-vinylpyridinium) hydrogen sulfate in glycerol. The present method affords non-toxic and non-corrosive medium, short reaction times, high yield of the products, mild reaction conditions as well as simple experimental and isolation procedures. The catalyst can be recycled by simple filtration and reused without any significant reduction in its activity. Taylor & Francis 2018 Article PeerReviewed Hamid, Sharifah Bee Abd and Titinchi, Salam J.J. and Abbo, Hanna and Khaligh, Nader Ghaffari (2018) One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives. Polycyclic Aromatic Compounds, 38 (2). pp. 189-198. ISSN 1040-6638 https://doi.org/10.1080/10406638.2016.1194298 doi:10.1080/10406638.2016.1194298
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Hamid, Sharifah Bee Abd
Titinchi, Salam J.J.
Abbo, Hanna
Khaligh, Nader Ghaffari
One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives
description An environmentally benign, simple, and efficient procedure has been developed for the one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives by the reaction of the variety of aryl-aldehydes, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and urea in the presence of catalytic amount of poly(N-vinylpyridinium) hydrogen sulfate in glycerol. The present method affords non-toxic and non-corrosive medium, short reaction times, high yield of the products, mild reaction conditions as well as simple experimental and isolation procedures. The catalyst can be recycled by simple filtration and reused without any significant reduction in its activity.
format Article
author Hamid, Sharifah Bee Abd
Titinchi, Salam J.J.
Abbo, Hanna
Khaligh, Nader Ghaffari
author_facet Hamid, Sharifah Bee Abd
Titinchi, Salam J.J.
Abbo, Hanna
Khaligh, Nader Ghaffari
author_sort Hamid, Sharifah Bee Abd
title One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives
title_short One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives
title_full One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives
title_fullStr One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives
title_full_unstemmed One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives
title_sort one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives
publisher Taylor & Francis
publishDate 2018
url http://eprints.um.edu.my/21965/
https://doi.org/10.1080/10406638.2016.1194298
_version_ 1643691712140279808

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