Platelet-rich concentrate in serum-free medium enhances cartilage-specific extracellular matrix synthesis and reduces chondrocyte hypertrophy of human mesenchymal stromal cells encapsulated in alginate

• Main Authors: Samuel, Shani, Raja Ahmad, Raja Elina Afzan, Ramasamy, Thamil Selvee, Karunanithi, Puvanan, Naveen, Sangeetha Vasudevaraj, Kamarul, Tunku
• Format: Article
• Published: Taylor & Francis 2019
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/23533/; https://doi.org/10.1080/09537104.2017.1371287
• Institution: Universiti Malaya

Platelet-rich concentrate (PRC), used in conjunction with other chondroinductive growth factors, have been shown to induce chondrogenesis of human mesenchymal stromal cells (hMSC) in pellet culture. However, pellet culture systems promote cell hypertrophy and the presence of other chondroinductive g...