Functional characterization of two variants in the 3’-untranslated region (UTR) of transcription factor 4 gene and their association with schizophrenia in sib-pairs from multiplex families

• Main Authors: Mohamed, Zahra Isnaini, Tee, Shiau Foon, Chow, Tze Jen, Loh, Siew Yim, Yong, Hoi Sen, Bakar, Abdul Kadir Abu, Tang, Pek Yee
• Format: Article
• Published: Elsevier 2019
• Subjects: QH Natural history; R Medicine
• Online Access: http://eprints.um.edu.my/24002/; https://doi.org/10.1016/j.ajp.2019.02.001
• Institution: Universiti Malaya

Transcription factor 4 (TCF4) gene plays an important role in nervous system development and it always associated with the risk of schizophrenia. Since miRNAs regulate targetgenes by binding to 3'UTRs of target mRNAs, the functional variants located in 3′UTR of TCF4 are highly suggested to affe...