Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic degradation of acetylsalicylic acid incorporated into tablets under humid conditions

Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic degradation of acetylsalicylic acid incorporated into tablets under humid conditions

The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First, powdered disintegrants were stored at conditions of 40 °C/7...

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Bibliographic Details
Main Authors: Ougi, Kousuke, Okada, Kotaro, Leong, Kok Hoong, Hayashi, Yoshihiro, Kumada, Shungo, Onuki, Yoshinori
Format: Article
Published: Elsevier 2020
Subjects:
R Medicine
RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/25439/
https://doi.org/10.1016/j.ejps.2020.105502
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Institution: Universiti Malaya

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http://eprints.um.edu.my/25439/
https://doi.org/10.1016/j.ejps.2020.105502

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