Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic degradation of acetylsalicylic acid incorporated into tablets under humid conditions

• Main Authors: Ougi, Kousuke, Okada, Kotaro, Leong, Kok Hoong, Hayashi, Yoshihiro, Kumada, Shungo, Onuki, Yoshinori
• Format: Article
• Published: Elsevier 2020
• Subjects: R Medicine; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/25439/; https://doi.org/10.1016/j.ejps.2020.105502
• Institution: Universiti Malaya

The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First, powdered disintegrants were stored at conditions of 40 °C/7...