The NLRP3 Inflammasome in Age-Related Cerebral Small Vessel Disease Manifestations: Untying the Innate Immune Response Connection

• Main Authors: Nassir, Che Mohd Nasril Che Mohd, Damodaran, Thenmoly, Ismail, Nurul Iman, Hashim, Sabarisah, Jaffer, Usman, Hamid, Hafizah Abdul, Mehat, Muhammad Zulfadli, Norazit, Anwar, Mustapha, Muzaimi
• Format: Article
• Published: MDPI 2023
• Subjects: R Medicine; Medical technology
• Online Access: http://eprints.um.edu.my/39064/
• Institution: Universiti Malaya

In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSV...