Discovery of therapeutics targeting oxidative stress in autosomal recessive cerebellar ataxia: A systematic review

• Main Authors: Lew, Sze Yuen, Phang, Michael Weng Lok, Chong, Pit Shan, Roy, Jaydeep, Poon, Chi Him, Yu, Wing Shan, Lim, Lee Wei, Wong, Kah Hui
• Format: Article
• Published: MDPI 2022
• Subjects: RB Pathology; RC Internal medicine
• Online Access: http://eprints.um.edu.my/41956/
• Institution: Universiti Malaya

Autosomal recessive cerebellar ataxias (ARCAs) are a heterogeneous group of rare neurodegenerative inherited disorders. The resulting motor incoordination and progressive functional disabilities lead to reduced lifespan. There is currently no cure for ARCAs, likely attributed to the lack of understa...