Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts

• Main Authors: Tsai, Yao-Tsung, Li, Chih-Yi, Huang, Yen-Hua, Chang, Te-Sheng, Lin, Chung-Yen, Chuang, Chia-Hsien, Wang, Chih-Yang, Anuraga, Gangga, Chang, Tzu-Hao, Shih, Tsung-Chieh, Lin, Zu-Yau, Chen, Yuh-Ling, Chung, Ivy, Lee, Kuen-Haur, Chang, Che-Chang, Sung, Shian-Ying, Yang, Kai-Huei, Tsui, Wan-Lin, Yap, Chee-Voon, Wu, Ming-Heng
• Format: Article
• Published: Springer Nature 2022
• Subjects: R Medicine; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/42878/
• Institution: Universiti Malaya

Most cases of hepatocellular carcinoma (HCC) arise with the fibrotic microenvironment where hepatic stellate cells (HSCs) and carcinoma-associated fibroblasts (CAFs) are critical components in HCC progression. Therefore, CAF normalization could be a feasible therapy for HCC. Galectin-1 (Gal-1), a be...