Sinomenine accelerate wound healing in rats by augmentation of antioxidant, anti-inflammatory, immunuhistochemical pathways

• Main Authors: Jabbar, Ahmed A.j., Abdul-Aziz Ahmed, Khaled, Abdulla, Mahmood Ameen, Abdullah, Fuad Othman, Salehen, Nur Ain, Mothana, Ramzi A., Houssaini, Jamal, Hassan, Rawaz Rizgar, Hawwal, Mohammed F., Fantoukh, Omer I., Hasson, Sidgi
• Format: Article
• Published: Elsevier 2024
• Subjects: R Medicine; RA Public aspects of medicine
• Online Access: http://eprints.um.edu.my/44899/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180090166&doi=10.1016%2fj.heliyon.2023.e23581&partnerID=40&md5=8fa619c02cfb062def197faff1468ed0
• Institution: Universiti Malaya

Sinomenine (SN) is a well-documented unique plant alkaloid extracted from many herbal medicines. The present study evaluates the wound healing potentials of SN on dorsal neck injury in rats. A uniform cut was created on Sprague Dawley rats (24) which were arbitrarily aligned into 4 groups receiving two daily topical treatments for 14 days as follows: A, rats had gum acacia; B, rats addressed with intrasite gel; C and D, rats had 30 and 60 mg/ml of SN, respectively. The acute toxicity trial revealed the absence of any toxic signs in rats after two weeks of ingestion of 30 and 300 mg/kg of SN. SN-treated rats showed smaller wound areas and higher wound closure percentages compared to vehicle rats after 5, 10, and 15 days of skin excision. Histological evaluation of recovered wound tissues showed increased collagen deposition, fibroblast content, and decreased inflammatory cells in granulated tissues in SN-addressed rats, which were statistically different from that of gum acacia-treated rats. SN treatment cause