Design, synthesis and anticolorectal cancer activity of 2- bromoalkoxyanthraquinones

• Main Authors: Lee, Yean Kee, Nurhaliza, Wati Mekzali, Cheok, Wui Chee, Iskandar, Abdullah, Nurshamimi, Nor Rashid, Vannajan, Sanghiran Lee, Rozana, Othman, Najihah, Mohd Hashim, Chin, Fei Chee
• Format: Conference or Workshop Item
• Language: English; English
• Published: 2024
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/45060/1/Lee%20Yean%20Kee-ACP2023-Abstract.pdf; http://eprints.um.edu.my/45060/2/Lee%20Yean%20Kee-ACP2023-Poster.pdf; http://eprints.um.edu.my/45060/; https://icceoca16.sg/
• Institution: Universiti Malaya

The impact of alkoxy chain length and the presence of a 1-hydroxy group in synthesised 2-bromoalkoxyanthraquinones was evaluated against HCT116, HT29, and CCD841 CoN cell lines. Molecular docking was employed to elucidate the interactions between these compounds and potential p53 and KRAS targets...