Exposure of Helicobacter pylori to clarithromycin in vitro resulting in the development of resistance and triggers metabolic reprogramming associated with virulence and pathogenicity

• Main Authors: Rosli, Naim Asyraf, Al-Maleki, Anis Rageh, Loke, Mun Fai, Tay, Sun Tee, Rofiee, Mohd Salleh, Teh, Lay Kek, Salleh, Mohd Zaki, Vadivelu, Jamuna
• Format: Article
• Published: Public Library of Science 2024
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/45478/; https://doi.org/10.1371/journal.pone.0298434
• Institution: Universiti Malaya

In H. pylori infection, antibiotic-resistance is one of the most common causes of treatment failure. Bacterial metabolic activities, such as energy production, bacterial growth, cell wall construction, and cell-cell communication, all play important roles in antimicrobial resistance mechanisms. Iden...