Thymoquinone Reverses Homocysteine-Induced Endothelial Dysfunction via Inhibition of Endoplasmic Reticulum-Stress Induced Oxidative Stress Pathway

• Main Authors: Sofiullah, Siti Sarah M., Murugan, Dharmani Devi, Abd Muid, Suhaila, Seng, Wu Yuan, Zamakshshari, Nor Hisam, Gan, Quan Fu, Patrick, Melonney, Ab Azis, Norasikin, Sirasanagandla, Srinivasa Rao, Woon, Choy Ker
• Format: Article
• Published: Penerbit Universiti Kebangsaan Malaysia 2024
• Subjects: Q Science (General); R Medicine (General)
• Online Access: http://eprints.um.edu.my/45530/; https://doi.org/10.17576/jsm-2024-5303-09
• Institution: Universiti Malaya

Hyperhomocysteinemia causes endoplasmic reticulum (ER) stress, which elevates reactive oxygen species (ROS) and induces endothelial dysfunction, the hallmark of cardiovascular diseases. Nigella sativa seeds contain thymoquinone (TQ), a cardioprotective bioactive component. Nevertheless, research on...