Molecular Dynamic Simulation and 3d-pharmacophore Modeling of Alpha Mangostin and Its Derivatives against Estrogen Alpha Receptor

Molecular Dynamic Simulation and 3d-pharmacophore Modeling of Alpha Mangostin and Its Derivatives against Estrogen Alpha Receptor

Background Human estrogen receptor alpha (ER alpha), which is known to play a role in mediating cell proliferation, metastasis, and resistance to apoptosis, is one of the targets of breast cancer therapies. Alpha mangostin (AM) is an active xanthone compound from Garcinia mangostana L. which has act...

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Bibliographic Details
Main Authors: Setyawati, Luthfi Utami, Parlan, Fateen Izzah Haziqah, Ikram, Nur Kusaira Khairul, Yusuf, Muhammad, Muchtaridi, Muchtaridi
Format: Article
Published: Bentham Science Publishers 2024
Subjects:
QD Chemistry
QH Natural history
Online Access:http://eprints.um.edu.my/45891/
https://doi.org/10.2174/1570180820666230220122600
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Institution: Universiti Malaya

Internet

http://eprints.um.edu.my/45891/
https://doi.org/10.2174/1570180820666230220122600

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