Solubility of Carbamazepine Co-Crystals in Ethanolic Solution

• Main Authors: Noor Ashila, Ramle, Syarifah, Abd Rahim, Nornizar, Anuar, El-Hadad, Omar
• Format: Conference or Workshop Item
• Language: English
• Published: AIP Publishing 2017
• Subjects: TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/18693/1/fkksa-2017-ashila-Solubility%20of%20Carbamazepine%20Co.pdf; http://umpir.ump.edu.my/id/eprint/18693/; http://dx.doi.org/10.1063/1.5000468
• Institution: Universiti Malaysia Pahang

The study aimed to determine the solubility of carbamazepine (CBZ) co-crystals formed from co-crystal formers (CCFs) of nicotinamide (NIC), saccharin (SAC), succinic acid (SUC) and fumaric acid (FUM) at various temperatures (25-50°C). High Performance Liquid Chromatography (HPLC) was used to determine the solubility and the X-Ray Powder Diffraction was used to characterize the crystals. The solubility of CBZ-NIC and CBZ-FUM co-crystals were found to be higher than the solubility of the CBZ for the range of studied temperatures. However, opposite findings was obtained for CBZ-SUC co-crystal as its solubility is lower than the solubility of CBZ. Different trend was found for CBZ-SAC co-crystal in which for temperature lower than 40°C, the solubility of CBZ crystal is higher than the CBZSAC co-crystal. The solubility of CBZ-SAC co-crystal is higher than the solubility of CBZ at a temperature above 40°C. CBZ co-crystals with NIC and FUM have shown to increase the solubility of CBZ by solubility ratio of 1.95 and 1.24 respectively. However, the CBZ co-crystal with SAC was found to have similar solubility value as the CBZ.