Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis

Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis

A series of aminated- (1–9) and sulfonamide-containing diarylpentadienones (10–18) were synthesized, structurally characterized, and evaluated for their in vitro anti-diabetic potential on α-glucosidase and DPP-4 enzymes. It was found that all the new molecules were nonassociated PAINS compounds. Th...

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Main Authors: Maryam Aisyah, Abdullah, Lee, Yu-Ri, Siti Nurulhuda, Mastuki, Leong, Sze Wei, Wan Norhamidah, Wan Ibrahim, Muhammad Alif, Mohammad Latif, Aizi Nor Mazila, Ramli, Mohd F. F., Mohd Aluwi, Siti Munirah, Mohd Faudzi, Kim, Cheol-Hee
Format: Article
Language:English
English
Published: Academic Press Inc. 2020
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/30212/1/Development%20of%20diarylpentadienone%20analogues%20as%20alpha-glucosidase%20inhibitor.pdf
http://umpir.ump.edu.my/id/eprint/30212/2/Development%20of%20diarylpentadienone%20analogues%20as%20alpha-glucosidase%20inhibitor_FULL.pdf
http://umpir.ump.edu.my/id/eprint/30212/
https://doi.org/10.1016/j.bioorg.2020.104277
https://doi.org/10.1016/j.bioorg.2020.104277
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Institution: Universiti Malaysia Pahang
Language: English
English

Internet

http://umpir.ump.edu.my/id/eprint/30212/1/Development%20of%20diarylpentadienone%20analogues%20as%20alpha-glucosidase%20inhibitor.pdf
http://umpir.ump.edu.my/id/eprint/30212/2/Development%20of%20diarylpentadienone%20analogues%20as%20alpha-glucosidase%20inhibitor_FULL.pdf
http://umpir.ump.edu.my/id/eprint/30212/
https://doi.org/10.1016/j.bioorg.2020.104277
https://doi.org/10.1016/j.bioorg.2020.104277

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