Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody

• Main Authors: Vulliez-Le Normand, Brigitte, W. Faber, Bart, A. Saul, Frederick, van der Eijk, Marjolein, W. Thomas, Alan, Balbir, Singh, H. M. Kocken, Clemens, A. Bentley, Graham
• Format: Article
• Language: English
• Published: Public Library of Science 2015
• Subjects: RB Pathology; RS Pharmacy and materia medica
• Online Access: http://ir.unimas.my/id/eprint/14851/1/Crystal.pdf; http://ir.unimas.my/id/eprint/14851/; http://www.scopus.com/inward/record.url?eid=2-s2.0-84928499366&partnerID=40&md5=7e72610acbee14a6c7b0a5aa1cdbbf7f
• Institution: Universiti Malaysia Sarawak

The malaria parasite Plasmodiumknowlesi, previously associated only with infection of macaques, is now known to infect humans as well and has become a significant public health problem in Southeast Asia. This species should therefore be targeted in vaccine and therapeutic strategies against human ma...