Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents

• Main Authors: Norsyafikah Asyilla, Binti Nordin, Tchan, Wei Chai, Bee, Ling Tan, Ching, Liang Choi, Ainaa Nadiah, Abd Halim, Hasnain, Hussain, Zainab, Ngaini
• Format: E-Article
• Language: English
• Published: Hindawi Publishing Corporation 2017
• Subjects: QD Chemistry
• Online Access: http://ir.unimas.my/id/eprint/15374/1/Novel%20Synthetic%20Monothiourea%20Aspirin%20Derivatives%20%28abstract%29.pdf; http://ir.unimas.my/id/eprint/15374/; https://doi.org/10.1155/2017/2378186
• Institution: Universiti Malaysia Sarawak

A new series of aspirin bearing alkylated amines moieties 1–12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16–56%. The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1H and 13C NMR spe...